Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GE_agg.GE_agg.cls#LTED_versus_MCF7p.GE_agg.cls#LTED_versus_MCF7p_repos |
| Phenotype | GE_agg.cls#LTED_versus_MCF7p_repos |
| Upregulated in class | MCF7p |
| GeneSet | MAPROTILINE HYDROCHLORIDE |
| Enrichment Score (ES) | -0.50816286 |
| Normalized Enrichment Score (NES) | -1.3152949 |
| Nominal p-value | 0.12266112 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | 1814 | NA | DRD3 Entrez, Source | dopamine receptor D3 | 1426 | 0.453 | 0.0181 | No |
| 2 | 3757 | NA | KCNH2 Entrez, Source | potassium channel, voltage gated eag related subfamily H, member 2 | 2639 | 0.291 | 0.0163 | No |
| 3 | 1812 | NA | DRD1 Entrez, Source | dopamine receptor D1 | 3023 | 0.255 | 0.0456 | No |
| 4 | 367 | NA | AR Entrez, Source | androgen receptor | 4147 | 0.175 | 0.0266 | No |
| 5 | 5871 | NA | MAP4K2 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 2 | 5098 | 0.127 | 0.0067 | No |
| 6 | 2847 | NA | MCHR1 Entrez, Source | melanin-concentrating hormone receptor 1 | 6619 | 0.076 | -0.0486 | No |
| 7 | 10919 | NA | EHMT2 Entrez, Source | euchromatic histone-lysine N-methyltransferase 2 | 6620 | 0.076 | -0.0348 | No |
| 8 | 3553 | NA | IL1B Entrez, Source | interleukin 1, beta | 7060 | 0.062 | -0.0433 | No |
| 9 | 1565 | NA | CYP2D6 Entrez, Source | cytochrome P450, family 2, subfamily D, polypeptide 6 | 9172 | 0.023 | -0.1352 | No |
| 10 | 1133 | NA | CHRM5 Entrez, Source | cholinergic receptor, muscarinic 5 | 10564 | 0.003 | -0.1980 | No |
| 11 | 6530 | NA | SLC6A2 Entrez, Source | solute carrier family 6 (neurotransmitter transporter), member 2 | 11224 | -0.007 | -0.2267 | No |
| 12 | 5050 | NA | PAFAH1B3 Entrez, Source | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | 11338 | -0.008 | -0.2304 | No |
| 13 | 55775 | NA | TDP1 Entrez, Source | tyrosyl-DNA phosphodiesterase 1 | 13012 | -0.038 | -0.2996 | No |
| 14 | 4194 | NA | MDM4 Entrez, Source | MDM4, p53 regulator | 13535 | -0.049 | -0.3144 | No |
| 15 | 9971 | NA | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 14056 | -0.060 | -0.3270 | No |
| 16 | 2831 | NA | NPBWR1 Entrez, Source | neuropeptides B/W receptor 1 | 14490 | -0.070 | -0.3339 | No |
| 17 | 1588 | NA | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 15107 | -0.086 | -0.3462 | No |
| 18 | 22861 | NA | NLRP1 Entrez, Source | NLR family, pyrin domain containing 1 | 16274 | -0.120 | -0.3774 | No |
| 19 | 4193 | NA | MDM2 Entrez, Source | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 18015 | -0.190 | -0.4217 | No |
| 20 | 3417 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 19917 | -0.337 | -0.4465 | Yes |
| 21 | 1576 | NA | CYP3A4 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 4 | 20305 | -0.385 | -0.3935 | Yes |
| 22 | 7098 | NA | TLR3 Entrez, Source | toll-like receptor 3 | 20836 | -0.475 | -0.3306 | Yes |
| 23 | 5243 | NA | ABCB1 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 21640 | -0.868 | -0.2081 | Yes |
| 24 | 5468 | NA | PPARG Entrez, Source | peroxisome proliferator-activated receptor gamma | 21841 | -1.224 | 0.0072 | Yes |
